No2-3(2) 2019
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Zabolotnyi DI, Sambur MB, Voroshylova NM, Verevka SV
Extracellular components of biofilms in the formation of antibiotic
resistance and chronicity of the inflammatory process. State of the problem |
Zabolotny Dmitry I
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Director
Doctor of Medical Sciences, Professor, Academician of the National Academy
of Medical Sciences of Ukraine
E-mail: amtc@kndio.kiev.ua
Sambur Marina B
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine
Deputy Director for Research
Doctor of Medical Sciences
Email: mbsambur@gmail.com
ORCID ID: http://orcid.org/0000-0002-9347-2829
Verevka Sergiy V.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine
Laboratory of biochemistry, manager
Doctor of Biological Sciences, Professor
Email: verevka.biochem@gmail.com
ORCID ID: http://orcid.org/0000-0002-3578-7996 |
Abstract
Permanent character of the improvement of resistance of living organisms to
the influence of adverse environmental factors is an integral property of
evolution. One of the manifestiations of this improvement is the formation
of the resistance of pathogens to antibiotics. The speed of formation and
spread of resistant pathogens complicates the treatment of diseases and
creates the danger of discarding of clinical medicine in the pre-antibiotic
era. The situation is complicated by the possibility of the formation of
multiresistance, which is the resistance of microbiological pathogens to
different types of antibiotics. Similarly to the most of microorganisms,
bacterial infectious agents exist mainly in the form of biofilms –
three-dimensional associate of microorganisms that are fixed by a matrix
from an extracellular polymeric substance, which is synthesized by the cells
themselves. The main topics of this work are the roles of extracellular
components of biofilms in the formation of antibiotic resistance, the need
for permanent death of the part of the cells for survive of the community of
microorganisms, and the effect of decay products on the adjacent tissues as
the premise for the chronicity of the inflammatory process.
The prospects of ultrasound destruction of biofilms for the suppression of
antibiotic resistance and the prevention of chronic inflammation are
discussed. |
Keywords
infectious diseases, antibiotic resistance, chronicity of inflammation,
biofilms. |
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