SCIENTIFIC-PRACTICAL JOURNAL

| укр | рус |

 

 
Home Editorial ethics For authors Current issue Archive Contacts

No3(3) 2020

Back to the issue


DOI 10.37219/2528-8253-2020-3-04
Bakaev A.A., Kovtunenko O.V., Tymchuk S.M.
Analysis of remote results of treatment of patients with maxillary sinus cancer
Bakaev Anatoly A.
State Institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine"
Department of Otolaryngology, Graduate student
Municipal enterprise «Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov» Dnipropetrovsk Regional Council
Department of Otorhinolaryngology No. 2 (oncological)
Otolaryngologist
Email: anatoliybakaev@gmail.com
Orchid ID: https://orcid.org/0000-0003-4192-7614

Kovtunenko Alexander V.
State Institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine"
Professor of the Department of Otolaryngology
Doctor of Medical Sciences
Email: lor@dsma.dp.ua
Orchid ID: https://orcid.org/0000-0002-0562-7684

Tymchuk Sergey N.
Municipal enterprise «Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov» Dnipropetrovsk Regional Council
Head of the Department of Otorhinolaryngology No. 2 (oncological)
Doctor of Medical Sciences
Email: sergej_lor@ukr.net
Orchid ID: https://orcid.org/0000-0002-8706-2313

Abstract

Maxillary sinus cancer is one of the most complex malignancies to treat and has an unfavorable prognosis for long-term outcomes.
The purpose of the study: based on the evaluation of long-term treatment outcomes (mortality, survival) to analyze the effectiveness of treatment of patients with maxillary sinus cancer and other factors which influence the outcome, including the level of expression of molecular markers.
Object and methods: Long-term results of surgical treatment of 103 patients with maxillary sinus cancer stage II-IV (T2-4N0-3M0) were evaluated, which was performed in the ENT oncology department of І.І. Mechnikov Dnipropetrovsk Regional Clinical Hospital over the period of 2011-2017. Remote follow-up of patients was conducted until 2019.
Results: The effectiveness of the treatment is confirmed by the analysis of survival in the studied sample: annual survival of 87.36% (95% CI 80.94-93.78); three-years’ survival – 42.75% (95% CI 33.2-52.3); five-years’ survival – 19.76% (95% CI 12.07-27.45); median survival – 32.13 (95% CI 27.0-53.0) months.
Using a regression analysis of the proportional risks by Cox, it was proved that patients with recurrences of thyroid cancer die from cancer 3.13 times more often (p=0.009) than individuals in whom cancer was not accompanied by recurrence, with increasing expression of the marker TIMP-1 per unit the risk of adverse outcomes for patients is reduced by 2.56 times (p=0.034).
Conclusions: Evaluation of long-term treatment outcomes (mortality, one-, three-, and five-years’ survival) of patients with maxillary sinus cancer has proven the effectiveness of treatment and approaches to their determination.

Keywords

maxillary sinus cancer, molecular markers, mortality, survival.


Reference

  1. Ansa B, Goodman M, Ward K, Kono SA, Owonikoko TK, Higgins K, et al. Paranasal sinus squamous cell carcinoma incidence and survival based of surveillance, epidemiology, and end results data, 1973 to 2009. Cancer. 2013;119(14):2602-10. doi: 10.1002/cncr.28108.
  2. Chen MM, Roman SA, Sosa JA, Judson BL. Predictors of Survival in Sinonasal Adenocarcinoma. J NeurolSurg B Skull Base. 2015
    Jun;76(3):208-13. doi: 10.1055/s-0034-1543995.
  3. Dubal PM, Bhojwani A, Patel TD, Zuckerman O, Baredes S, Liu JK, et al. Squamous cell carcinoma of the maxillary sinus: A population-based analysis. Laryngoscope. 2016 Feb;126(2):399-404. doi: 10.1002/lary.25601.
  4. Harvey RJ, Dalgorf DM. Chapter 10: Sinonasal malignancies. Am J Rhinol Allergy. May-Jun 2013;27 Suppl 1:S35-8. doi: 10.2500/ajra.2013.27.3894.
  5. Jain S, Li Y, Kuan EC, Tajudeen BA, Batra PS. Prognostic Factors in Paranasal Sinus Squamous Cell Carcinoma and Adenocarcinoma: A SEER Database Analysis. J Neurol Surg B Skull Base. 2019 Jun;80(3):258-263. doi: 10.1055/s-0038-1669420.
  6. Kovtunenko OV, Bakaiev АА, Shponka IS. Analysis of expression of p63 and caspase-3 and theirpredictivevalue in patients with squamous cell carcinoma of maxillary sinus. Wiadomości Lekarskie. 2019; LXXII(12.I): 2305-14. doi: 10.36740/WLek201912108.
  7. Kreppel M, Danscheid S, Scheer M, Lüers JC, Eich HT, Zöller JE, etal. Neoadjuvant chemoradiation in squamous cell carcinoma of the maxillary sinus: a 26-year experience. Chemother Res Pract. 2012;2012:413589. doi: 10.1155/2012/413589.
  8. Lukach E, Serezhko Ju, Ternyc’ka Ju. [Tumors of the nose and paranasal sinuses]. Rynologija. 2006;4:3-13. [in Ukrainian].
  9. Lund VJ, Clarke PM, Swift AC, McGarry GW, Kerawala C, Carnell D. Nose and paranasal sinus tumours: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):S111-S118. doi:10.1017/S0022215116000530.
  10. Mody, M.D., Saba, N.F. Multimodal Therapy lor Sinonasal Malignancies: Updates and Review of CurrentTreatment. Curr. Treat. Options in Oncol.
    2020;21 (1): 4. doi.org/10.1007/s11864-019-0696-4.
  11. Petrie A, Sabin C. Medical Statistics at a Glance. 3th ed. Oxford: Wiley Blackwell; 2013. 180 p.
  12. Robin TP, Jones BL, Gordon OM, Phan A, Abbott D, McDermott JD, et al. A comprehensive comparative analysis of treatment modalities lor sinonasal
    malignancies. Cancer. 2017 Aug 15;123(16):3040-9. doi: 10.1002/cncr.30686.
  13. Santos MR, Servato JP, Cardoso SV, de Faria PR, Eisenberg AL, Dias FL, et al. Squamous cell carcinoma at maxillary sinus: clinicopathologic data in a single Brazilian institution with review of literature. Int J Clin ExpP athol. 2014 Dec 1;7(12):8823-32. PMID: 25674251; PMCID: PMC4313952.
  14. Skomorokhova TV. [Optimization of planning and radiotherapy for patients with upper respiratory tract tumors] [dissertation]. Kyiv: National Cancer
    Institute; 2018. 207. [in Ukrainian].
  15. Unsal AA, Dubal PM, Patel TD, et al. Squamous cell carcinoma of the nasal cavity: A population-based analysis. Laryngoscope. 2016; 126(3):560-5. doi:10.1002/lary.25531.
  16. Vazquez A, Khan MN, Blake DM, Patel TD, Baredes S, Eloy JA. Sinonasalsquamous-cellcarcinoma and the prognostic implications of its histologic variants: a population-based study. Int Forum Allergy Rhinol. 2015;5(1):85-91. doi:10.1002/alr.21418.
  17. Zabolotny DI, Lukach EV, Dihtyaruk VJ, Tsymbalyuk EM, Zaitseva NV, Strezhak VV, Kutsenko LB. [Five-year survival rate of patients with malignant neoplasms of nose cavity and paranasal sinuses in Ukraine]. Rynologija. 2011;4:46-60. [in Ukrainian].
 

© 2019, Public Organization «Ukrainian Scientific Medical Society of Otorhinolaryngologists»