SCIENTIFIC-PRACTICAL JOURNAL

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No3(4) 2021

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DOI 10.37219/2528-8253-2021-3-66

Kosakovskyi A., Golovnia O., Gunko S., Kosakivska I.
Determination of antimicrobial action of "Apicold oral spray"
Kosakovsky Anatoly L.
Shupyk National Healthcare University of Ukraine
Head of Department of Pediatric Otorhinolaryngology, Audiology, Phoniatrics
Doctor of Medical Sciences, Professor
E-mail: akosakovskyi@gmail.com
ORCID ID: 0000-0001-7194-420X

Golovnya Oksana M.
Ukrainian Reference Center for Clinical Laboratory Diagnostics and Metrology
Head of the Bacteriological Laboratory
e-mail: om.golovnia@gmail.com

Gunko Svitlana G.
Ukrainian Reference Center for Clinical Laboratory Diagnostics and Metrology
Bacteriologist at bacteriological laboratory
e-mail: baklab_ohmatdyt@ukr.net

Kosakivska Ilona A.
Shupyk National Healthcare University of Ukraine
Department of Pediatric Otorhinolaryngology, Audiology, Phoniatrics
Candidate of Medical Sciences
Associate Professor
Email: akosakovskyi@gmail.com
ORCID ID: 0000-0002-6358-2533

Abstract

Introduction: The causative agents of acute tonsillopharyngitis are viruses and bacterial flora. Treatment of acute pharyngitis is mainly local, which includes aerosols with antiseptics.
Aim: Study of antimicrobial action of "Apicold oral spray" on clinical isolates of microorganisms Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Candida albicans isolated from patients' oropharynx in patients.
Material and methods: The effect of Apicold Oral Spray (manufactured by APIPHARMA doo) on clinical isolates of Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, and Candida albicans in Ukrainian patients was studied. Antimicrobial activity was assessed after 5, 10 and 20 minutes of action of one dose of "Apicold oral spray" on microorganisms. Bactericidal and fungicidal action (inhibition of cell growth of microorganisms) is expressed as a percentage according to the control.
Results and discussion: Apicold Oral Spray has a 100% antimicrobial effect after 5 minutes on clinical isolates of Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Candida albicans (complete growth inhibition of all 5 clinical isolates after 20 minutes).
Conclusion: "Apicold oral spray" has a high antimicrobial effect on clinical isolates of Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Candida albicans, which is confirmed by 100% inhibition of the growth of all bacteria after 5 minutes

Keywords

"Apicold oral spray", bacteria, viruses, acute tonsillopharyngitis, acute pharyngitis, protective propolis-glycerin film, propolis.


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