No3-4(5) 2022
Back to the issue
DOI 10.37219/2528-8253-2022-3-23 |
Pochuieva TV, Filatova GA
Peculiarities of bone tissue metabolism in patients with acute otitis media
with impared carbonhydrate metabolism |
Pochuiеva Tatiana V.
Department of Otorhinolaryngology and Pediatric Otolaryngology,Professor
Kharkiv Academy of Postgraduate Education
Email: pochuevatv@ukr.net
ORCID ID: https://orcid.org/0000-0002-4138-7091
Filatova Anna A.
Department of Otorhinolaryngology and Pediatric Otolaryngology
Kharkiv Academy of Postgraduate Education
Email : ane4kafilatova@ukr.net
ORCID ID: https://orcid.org/0000-0002-7480-754X |
Abstract
Introductions: Relevance of the study is due to the unrecognized
effect of carbohydrate metabolism disorders on bone tissue metabolism in
patients with acute otitis media (AOM).
Aim: to determine the peculiarities of bone tissue metabolism in
patients with AOM caused by disorders of carbohydrate metabolism.
Materials and methods: Our study included 73 patients aged 18 to 79
(29 males and 44 females) who were randomized into 4 groups according to the
aim of the research:
Group 1 – 17 patients with AOM,
Group 2 – 15 patients with AOM combined with paranasal sinus pathology,
Group 3 – 20 patients with AOM on the background of type 2 diabetes
mellitus,
Group 4 – 21 patients with AOM combined with transitory disorders of glucose
metabolism.
On the basis of clinical examination all patients were tested for
glycosylated hemoglobin (HbAlc), blood calcium level and parathormone as a
marker of bone resorption and osteocalcin as a marker of bone remodeling.
Results of the study and discussion: The statistical evaluation of
the indicators identified a reliable difference between groups 1-2 and
groups 3-4, while between groups 1 and 2, 3 and 4 reliable difference in
metabolic parameters of bone tissue has not been established. The level of
glucosylated hemoglobin was significantly elevated even for transitory signs
of carbohydrate metabolism disorders (5,17±0,17%, 4,95±0,17%, 9,8±0,46% and
7,78±0,19% in groups 1,2, 3 and 4 respectively).The value of parathormone
was within the reference values, but it proved to be significantly (p˂0,001)
higher in glucose metabolism disorders (56.8±3.02pg/ml and 52.56±2.7pg/ml in
groups 3 and 4, respectively).The amount of osteocalcin and calcium tended
to decrease in type 2 diabetes
mellitus (group 3) and in transitory disorders (group 4), but without a
significant difference (p˃0.05).
Correlation analysis revealed a strong correlation between glucose and
glucosylated hemoglobin levels in patients in group 3 and the average
strength in patients in group 4 (r=0.832 and r=0.44, respectively). The
increase of parathormone level on the basis of carbohydrate metabolism
disorders was due to the presence of correlation with the level of
glucosylated haemoglobin in groups 3 and 4 (r=0.705 and r=0.81
respectively). Calcium correlations of r=-0.77 and r=-0.56 with parathormone
level and r=-0.79 and r=-0.44 with glucosylated haemoglobin level were found
in patients of groups 3 and 4 accordingly. In the absence of glucose
metabolism disorders in groups 1 and 2, no significant correlations were
found, except for physiologically determined correlations of parathormone
and calcium levels in group 1 (r=-0.489).
Conclusions: Disorders of carbohydrate metabolism negatively affect
metabolism of bone tissue due to activation of bone resorption processes.
This is manifested by correlated with the level of glycosylated hemoglobin
by an increase in the amount of parathormone with pathogenetic significance
of both type 2 diabetes mellitus and transitory disorders of carbohydrate
metabolism.In this category of patients, the level of parathormone and its
dynamics, as well as the determination of glucosylated hemoglobin are
informative even in transitory disorders of carbohydrate metabolism. |
Keywords
bone metabolism, carbohydrate metabolism disorders, acute otitis media,
parathormone, glucosylated hemoglobin. |
Reference
- Bezeha MI. [Improving the efficiency of treatment of patients with
acute otitis media complicated mastoidit is using modified conservative
and surgical techniques] [dissertation]. Kiev: State Institution «O. S.
Kolomiychenko Institute of otolaryngology of National academy of medical
sciences of
Ukraine»; 2018. 186 p. Available from: http://www.iol.com.ua/article/bezega_dis.pdf.
[In Ukrainian].
- Botella Martínez S, Varo Cenarruzabeitia N, Escalada San Martin J,
Calleja Canelas A. The diabetic paradox: Bone mineral density and
fracture in type 2 diabetes. Endocrinol Nutr. 2016;63(9):495-501. doi:
10.1016/j.endonu.2016.06.004.
- Chitadze K, Jorbenadze T, Adamia M. [Pathomorphological changes
under latent mastoiditis]. Georgian Med News. 2017;(267):111-4. [Article
in Russian].
- Compston J. Type 2 diabetes mellitus and bone. J Intern Med.
2018;283(2):140-153. doi: 10.1111/joim.12725. [Article in English].
- Furst JR, Bandeira LC, Fan WW, Agarwal S, Nishiyama KK, McMahon DJ,
Dworakowski E, Jiang H, Silverberg SJ, Rubin MR. Advanced Glycation
Endproducts and Bone Material Strength in Type 2 Diabetes. J Clin
Endocrinol Metab. 2016;101(6):2502-10. doi:10.1210/jc.2016-1437.
- Golz A, Netzer A, Goldenberg D, Westerman ST, Westerman LM, Joachims
HZ. The association between iron-deficiency anemia and recurrent acute
otit is media. Am J Otolaryngol. 2001;22(6):391-4.
doi:10.1053/ajot.2001.28075.
- Kanazawa I, Sugimoto T. Diabetes Mellitusinduced Bone Fragility.
Intern Med. 2018;57(19): 2773-85. doi:10.2169/internalmedicine.0905-18.
- Kanazawa I. Interaction between bone and glucose metabolism
[Review]. Endocr J. 2017;64(11): 1043-53. doi:10.1507/endocrj.EJ17-0323.
- Kenna MA. Otitis media and the new guidelines. J Otolaryngol.
2005;34 Suppl 1:S24-32.
- Khoruziy OI. [Pathomorphological and clinical and biochemical
assessment of treatment tactics for acute otitis media with sensoneural
hearing loss] [dissertation]. Thernopol: I. Horbachevsky Ternopil
National Medical University; 2015. 143 p. Available from: http://www.iol.com.ua/article/khoruziy_dis.pdf.
[In Ukrainian].
- Krivopalov AA, Fanta IV. [Acute otitis media: epidemiology,
classification, etiology and treatment]. Medical Council. 2016;(4):53-5.
https://doi.org/10.21518/2079-701X-2016-4-53-55. [Article in Russian].
- Laulajainen Hongisto A, Jero J, Markkola A, Saat R, Aarnisalo AA.
Severe Acute Otitis Media and Acute Mastoiditis in Adults. J Int Adv
Otol. 2016;12(3):224-30. doi:10.5152/iao.2016.2620.
- Lewiecki EM. Management of skeletal health in patients with
asymptomatic primary hyperparathyroidism. J Clin Densitom.
2010;13(4):324-34. doi:10.1016/j.jocd.2010.06.004.
- Makras P, Anastasilakis AD. Bone disease in primary
hyperparathyroidism. Metabolism. 2018;80: 57-65. doi:
10.1016/j.metabol.2017.10.003.
- Malovana IV. [Differentiated approaches to correction of metabolic
disorders in patients with purulent otit is media] [dissertation].
Ternopil: Ternopil National Medical University; 2008. 168 p. [In
Ukranian].
- Monasta L, Ronfani L, Marchetti F, Montico M, Vecchi Brumatti L,
Bavcar A, Grasso D, Barbiero C, Tamburlini G. Burden of disease caused
by otitis media: systematic review and global estimates. PLoS One.
2012;7(4):e36226.
https://doi.org//10.1371/journal.pone.0036226.
- Murgasova L, Jurovcik M, Jesina P, Malinova V, Bloomfield M, Zeman
J, Magner M. Otorhinolaryngological manifestations in 61 patients with
mucopolysaccharidosis. Int J Pediatr Otorhinolaryngol. 2020;135:110137. doi:10.1016/j.ijporl.
2020.110137.
- Pochuieva TV, Filatova GA, Filatova IV, Iyevleva
VI. [Pathogenetic significance of hyperglycemia in
the format ion of the course peculiarities of acute
otit is media and its complicat ions]. International
Medical Journal. 2022;4:71-9. [Article in Ukrainian].
- Pochuieva TV, Filatova IV, Miroshnichenko OS,
Filatova GA. Clinical portrait of a patient with
type 2 diabetes mellitus as the basis for the specific
course of acute otitis media. Otolaryngology.
2021; 4(6): 14-25. DOI 10.37219/2528-8253-2021-6-14. [Article in Ukrainian].
- Pochuiеva T, Filatova A, Filatova I. Features of
the clinical course of acute otitis media in patients
with impared carbonhydrate metabolism. EUREKA: Health Sciences. 2022;(1):17-29. doi:
http://doi.org/10.21303/2504-5679.2022.002280.
- Rijk MH, Hullegie S, Schilder AGM, Kortekaas
MF, Damoiseaux RAMJ, Verheij TJM, Venekamp
RP. Incidence and management of acute otitis media in adults: a primary care-based cohort study.
Fam Pract. 2021;38(4):448-53. doi: 10.1093/ fampra/cmaa150.
- Sanches CP, Vianna AGD, Barreto FC. The impact of type 2 diabetes on bone metabolism. Diabetol Metab Syndr. 2017;9:85. doi:10.1186/s13098-017-0278-1.
- Schilder AG, Marom T, Bhutta MF, Casselbrant
ML, Coates H, Gisselsson-Solén M, Hall AJ,
Marchisio P, Ruohola A, Venekamp RP, Mandel
EM. Panel 7: Otitis Media: Treatment and Complications. Otolaryngol Head Neck Surg.
2017;156(4_suppl):S88-S105. doi: 10.1177/0194599816633697.
- Seidel DU, Bode S, Kostev K, Park JJ. Incidence
of Inner Ear Disorders in Various Forms of Acute
Otitis Media in ENT Practices in Germany. Ear
Nose Throat J. 2021;100(3_suppl):325S-332S. doi:
10.1177/0145561320930568.
- Shirai N, Preciado D. Otitis media: what is new?
Curr Opin Otolaryngol Head Neck Surg. 2019;27
(6):495-8.doi:10.1097/MOO.0000000000000591.
- Smith A, Gutteridge I, Elliott D, Cronin M. Acute
otitis media associated bilateral sudden hearing
loss: case report and literature review. J Laryngol
Otol. 2017;131(S2):S57-S61. doi: 10.1017/
S0022215117000779.
- Tanninex E. [Peculiarities of the clinical course of
acute mastoiditis]. Zhurnal ushnyh, nosovyh i gorlovyh boleznej. 2003;(2):86-8. [In Ukrainian]
- Vaidya V, Gangan N, Sheehan J. Impact of cardiovascular complications among patients with Type
2 diabetes mellitus: a systematic review. Expert
Rev Pharmacoecon Outcomes Res. 2015;15(3):
487-97. doi:10.1586/14737167.2015.1024661.
- Wiertsema SP, Veenhoven RH, Sanders EA,
Rijkers GT. Immunologic screening of children
with recurrent otitis media. Curr Allergy Asthma Rep. 2005;5(4):302-7.
doi:10.1007/s11882-005-0070-4.
- Wilmot EG, Davies MJ, Yates T, Benhalima K,
Lawrence IG, Khunti K. Type 2 diabetes in younger adults: the emerging
UK epidemic. Postgrad Med J. 2010;86(1022):711-8. doi: 10.1136/
pgmj.2010.100917.
- Yashan AI, Khoruzhy IV. [The influence of dead lymphocytes from
middle ear secretion on the development of sensorineural hearing
impairment associated with acute otitis media]. Vestn Otorinolaringol. 2015;(1):17-20. doi: 10.17116/otorino
201580117-20. [Article in Russian].
- Zhao C, Liu G, Zhang Y, Xu G, Yi X, Liang J,
Yang Y, Liang J, Ma C, Ye Y, Yu M, Qu X. Association between serum levels of bone turnover
markers and bone mineral density in men and
women with type 2 diabetes mellitus. J Clin Lab
Anal. 2020;34(4):e23112. doi: 10.1002/jcla.
23112.
- Zheng Y, Ley SH, Hu FB. Global aetiology and
epidemiology of type 2 diabetes mellitus and its
complications. Nat Rev Endocrinol. 2018;14(2):
88-98. doi:10.1038/nrendo.2017.151.
|
|